Citrulline and Nitric Oxide Production: JISSN Position Stand

## Summary

The JISSN review by Gonzalez AM & Trexler ET from 2020 analyzes citrulline supplementation and was published in the Journal of the International Society of Sports Nutrition.

Study Background

This review examines the effects of L-citrulline and citrulline malate on arginine levels, nitric oxide (NO) production, and athletic performance.

Main Findings

The review shows: - Optimal dose: 6-8g citrulline malate or 3-6g L-citrulline - Timing: 60-90 minutes before training - Mechanism: Citrulline → Arginine → NO → Vasodilation → "Pump" - Performance: Improved endurance in high-repetition sets - Superiority: Citrulline more effective than arginine (better bioavailability)

Methodology

Review is based on clinical studies on citrulline supplementation and NO production.

Scientific Classification (No approved Health Claims)

Please note: The following information describes scientific study results. They do not constitute recommendations for health claims and must not be used as such.

These review findings are relevant for: - Scientific product development: Citrulline malate vs. L-citrulline formulations - Study results: NO production and pump mechanisms - Dosage studies: 6-8g citrulline malate 60-90 minutes before training - Transparency: Superiority over arginine supplementation

Source

The full review is freely accessible.

Authors: Gonzalez AM, Trexler ET Year: 2020 Journal: Journal of the International Society of Sports Nutrition DOI: 10.1186/s12970-020-00349-4

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*Note: This summary is for informational purposes. The presented study results are not approved health claims. For detailed information, please consult the original source.*